SINGLE CELL LINEAGE TRACING REVEALS CLONAL DYNAMICS OF ANTI-EGFR THERAPY RESISTANCE IN TRIPLE NEGATIVE BREAST CANCER

Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer

Abstract Background Most primary Triple Negative Breast Cancers (TNBCs) show amplification of Pillow Protector the Epidermal Growth Factor Receptor (EGFR) gene, leading to increased protein expression.However, unlike other EGFR-driven cancers, targeting this receptor in TNBC yields inconsistent therapeutic responses.Methods To elucidate the underly

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Hyperkeratotic palmoplantar lichen planus in a child

Lichen planus (LP) is a common idiopathic inflammatory disorder that affects the flexor aspect of the wrists, the legs, and the oral and genital BOREAL BODY LOTION mucosa.Depending upon the site of involvement, LP can be divided into mucosal, nail, scalp, or palmoplantar types.Palmoplantar LP can pose a diagnostic problem to the clinician as it res

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Comparative effectiveness of hybrid and laparoscopic techniques for repairing complex incisional ventral hernias: a systematic review and meta-analysis

Abstract Background The recently developed Hybrid Hernia Repair technique (HHR), an adaptation of the laparoscopic method, has Play Mat been proposed as a potential alternative for the treatment of complex Incisional Ventral Hernias (IVH).While single-arm studies have reported promising outcomes, a comprehensive meta-analysis affirming these benefi

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Anisotropic excitation of surface plasmon polaritons on a metal film by a scattering-type scanning near-field microscope with a non-rotationally-symmetric probe tip

We investigated the excitation of surface plasmon polaritons on gold films with the metallized probe tip of a scattering-type scanning near-field optical microscope (s-SNOM).The emission of the polaritons from the tip, illuminated by near-infrared laser radiation, was found to be anisotropic and not circularly symmetric as expected on foot rear lef

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A comprehensive multiplex PCR based exome-sequencing assay for rapid bloodspot confirmation of inborn errors of metabolism

Abstract Background Tandem mass spectrometry (MS MS) and simple fluorometric assays are currently used in newborn screening programs to detect inborn errors of metabolism (IEM).The aim of the study was to evaluate the clinical utility of Ointment exome sequencing as a second tier screening method to assist clinical diagnosis of the newborn.Methods

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